Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A

Gavin Carr; Marco K W Chung; A Grant Mauk; Raymond J Andersen

doi:10.1021/jm800143h

Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A

J Med Chem. 2008 May 8;51(9):2634-7. doi: 10.1021/jm800143h. Epub 2008 Apr 8.

Authors

Gavin Carr¹, Marco K W Chung, A Grant Mauk, Raymond J Andersen

Affiliation

¹ Departments of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.

PMID: 18393489
DOI: 10.1021/jm800143h

Abstract

Synthetic analogues of the sponge natural product exiguamine A (3) have been prepared and evaluated for their ability to inhibit indoleamine 2,3-dioxygenase in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase / antagonists & inhibitors*
Indoleamine-Pyrrole 2,3,-Dioxygenase / chemistry
Indoles / chemical synthesis*
Indoles / chemistry
Kinetics
Porifera / chemistry*
Recombinant Proteins / antagonists & inhibitors
Recombinant Proteins / chemistry
Spiro Compounds / chemical synthesis*
Spiro Compounds / chemistry
Structure-Activity Relationship

Substances

Indoleamine-Pyrrole 2,3,-Dioxygenase
Indoles
Recombinant Proteins
Spiro Compounds
exiguamine A